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Fast and accurate assessment of skin mechanics holds great promise in diagnosing various epidermal diseases, yet substantial challenges remain in developing simple and wearable strategies for continuous monitoring. Here, we present a design concept, named active near-infrared spectroscopy patch (ANIRP) for continuously mapping skin mechanics. ANIRP addresses these challenges by integrating near-infrared (NIR) sensing with mechanical actuators, enabling rapid measurement (<1 s) of Young’s modulus, high spatial sensing density (~1 cm²), and high spatial sensitivity (<1 mm). Unlike conventional electromechanical sensors, NIR sensors precisely capture vibrational frequencies propagated from the actuators without needing ultraclose contact, enhancing wearing comfort. Demonstrated examples include ANIRPs for comprehensively moduli mapping of artificial tissues with varied mechanical properties emulating tumorous fibrosis. On-body validation of the ANIRP across skin locations confirms its practical utility for clinical monitoring of epidermal mechanics, promising considerable advancements in real-time, noninvasive skin diagnostics and continuous health monitoring. 

Abstract Transdermal drug delivery is of vital importance for medical treatments. However, user adherence to long-term repetitive drug delivery poses a grand challenge. Furthermore, the dynamic and unpredictable disease progression demands a pharmaceutical treatment that can be actively controlled in real-time to ensure medical precision and personalization. Here, we report a spatiotemporal on-demand patch (SOP) that integrates drug-loaded microneedles with biocompatible metallic membranes to enable electrically triggered active control of drug release. Precise control of drug release to targeted locations (<1 mm²), rapid drug release response to electrical triggers (<30 s), and multi-modal operation involving both drug release and electrical stimulation highlight the novelty. Solution-based fabrication ensures high customizability and scalability to tailor the SOP for various pharmaceutical needs. The wireless-powered and digital-controlled SOP demonstrates great promise in achieving full automation of drug delivery, improving user adherence while ensuring medical precision. Based on these characteristics, we utilized SOPs in sleep studies. We revealed that programmed release of exogenous melatonin from SOPs improve sleep of mice, indicating potential values for basic research and clinical treatments. 

Abstract Precision healthcare relies upon ubiquitous biofeedback to optimize therapy individually for nuanced and dynamic needs. However, grand challenges reside in the lack of soft, highly personalizable monitors that are scalable in manufacturing and reversibly interchangeable upon the evolution of needs. Herein, a customizable soft wearable platform is presented that can seamlessly integrate diverse functional modules, including physical and biochemical sensors, stimulators, and energy storage devices, tailored to various health monitoring scenarios, while can self‐repair after certain mechanical damage. The platform supports versatile physiological sensing and therapeutic intervention due to its compatibility with wide‐ranging functional nanomaterials. A bilayer microporous foam embedded in the gel improves sweat management for comfortable and reliable on‐body biomarker monitoring. Furthermore, flexible self‐healing zinc‐air batteries using ion gel electrolytes provide opportunities for self‐powered, closed‐loop systems. On‐body demonstrations validate the platform's capability to monitor physiological and metabolic states under real‐world conditions. This work provides a scalable and adaptable materials‐based solution for real‐time personalized health monitoring, advancing wearable bioelectronics to meet evolving healthcare demands.